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PARP Inhibitor BSI-201 Improves Survival for Metastatic Triple Negative

Adding the investigational drug BSI-201, a PARP inhibitor, to gemcitabineand carboplatin chemotherapy improves survival by almost 60 percent in patients with metastatic triple-negative breast cancer (estrogen-receptor, progesterone-receptor, and HER2 negative), in comparison to chemo alone. Results of a Phase II study presented at the San Antonio Breast Cancer Symposium replicate previous findings on PARP inhibitors, which interfere with the ability of cancer cells to repair themselves, making them more vulnerable to chemotherapy.

Reference: O’Shaughnessy J, et al “Updated results of a randomized phase II study deonstrating efficacy and safety of BSI-201, a PARP inhibitor, in combination with gemcitabine/carboplatin in metastatic triple-negative breast cancer” SABCS 2009; Abstract 3122.

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