Targeting a specific enzyme—O-GlcNAc transferase (OGT)— can kill triple-negative breast cancer cells but spare non-tumor cells, according to a study in the online edition of Molecular Cell.
Researchers discovered that reducing levels of OGT or blocking OGT activity selectively killed cancer cells but spared non-cancer breast cells. This reduces critical metabolites involved in energy production that feeds cancer growth and survival. 
The team showed that TNBC tumors contain higher expression of OGT and HIF-1a compared to other breast cancer subtypes. These results provide evidence that targeting OGT may provide targeted therapy for TNBC.

• Edited from a news release from Drexel University College of Medicine.

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One thought on “Enzyme Kills TNBC And Spares Non-Cancerous Cells

  1. Anonymous says:

    Hi Patricia, just found your page, very much needed. I am supporting my wife who was diagnosed TNBC Nov. 2013, did eight sets of chemo, two drugs each time, about to finish radiation. She tolerated the chemo better than expected, she has four radiation treatments left. She feels remarkably well for what she has been through. I volunteered to be the head researcher in all of this, it allows her to work on her mental state and not get too depressed about things. What I am surprised at in regards to modern Western medicine is; when we basically did an outgoing interview with the oncologist prior to radiation we asked what she should do once she's completed it. His response is to do nothing but get rest, proper diet, and exercise. Assume you're cured. You don't need any tests, his explanation makes some sense- more exposure to radiation, false readings, etc. That part makes a little sense. Follow-up appointment in six months. It just seems odd to me that as far as they are concerned, we're done, unless something “pops-up” and/or she starts having unexplainable aches, pains, etc. I'm not one for sitting back and playing the waiting game- it is like playing Russian Roulette. I believe in being pro-active, especially through that critical 5-8 year window. I'm considering having the genome testing done in case there is something out there that may help keep it from recurring-and just to have more information about her subtype; why wait and see if it comes back and metastasizes? Please keep the info flowing, there is a shortage of good news sometimes. Kindest regards, Greg.

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