Improving metabolic factors may help improve survival in postmenopausal women with triple-negative breast cancer, according to research presented at the 2019 San Antonio Breast Cancer Symposium. These factors, which include weight gain, reduced activity and insulin resistance, can be an issue for women diagnosed with TNBC and may have serious repercussions for health overall.
Researchers compared these factors, also called metabolic syndrome, with survival rates in women diagnosed with TNBC who participated in the Women’s Health Initiative (WHI), enrolled from 1993 to 1998.
The average time from enrollment to TNBC diagnosis was 8.6 years; women with the most metabolic components had a significantly shorter time (7 years) to diagnosis than those without any metabolic syndrome components (9.8 years). Women with TNBC and 3 to 4 metabolic components had 10-year all-cause survival rates 35% lower than TNBC survivors with no metabolic syndrome components.
• 29% of the women (178 patients) had no metabolic syndrome components.
• 53% had 1 to 2 components (323 patients).
• 7% had 3 to 4 components (43 patients).
• Those with the most metabolic syndrome components were often black.
• Patients with income under $50,000 a year were more likely to have a greater number of metabolic components.
The conclusion: Greater attention should be given to issues such as weight gain, physical activity, and insulin levels.
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