Some triple-negative breast cancer tumors may benefit from JAK inhibitors, a class of anti-inflammatory drugs currently used to treat rheumatoid arthritis, according to research in Cell Reports.
These tumors rely on an antiviral pathway related to inflammation, widely recognized for roles in cancer, rheumatoid arthritis, and other inflammatory diseases. Biologically, they have mutations of the proteins p53 and ARF.
“There are JAK inhibitors in use for rheumatoid arthritis and being tested against a number of other conditions,” said senior author Jason D. Weber, PhD, of the Washington University School of Medicine in St. Louis, Missouri
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